NAD+ is one of the most talked-about molecules in longevity research. But what can it actually do for you, and is IV delivery worth the investment? Here is what we know.
Nicotinamide adenine dinucleotide — NAD+ — is a coenzyme present in every cell of your body. It plays a central role in energy metabolism, DNA repair, and cellular signaling. The problem: NAD+ levels decline steadily with age, dropping by roughly 50% by the time you hit 50.
What NAD+ IV Therapy Claims to Do
Providers offering NAD+ IV therapy suggest it can boost energy, sharpen mental clarity, support recovery from exercise, and help with symptoms of jet lag or burnout. Some clinicians use it as part of addiction recovery protocols.
What the Research Supports
Human data on NAD+ IV therapy is limited. The strongest evidence exists for oral NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), which have demonstrated increases in blood NAD+ levels in clinical trials. The leap from oral supplementation to IV delivery of NAD+ itself is where the evidence gets thin.
What is well-established: NAD+ is essential for sirtuin function, which governs cellular stress responses and mitochondrial health. Declining NAD+ is a legitimate biochemical marker of aging. Whether restoring it via IV infusion produces meaningful, lasting benefits is not yet proven.
The Practical Reality
Most people who receive NAD+ IV therapy report feeling more alert for 24–72 hours afterward — similar to a strong cup of coffee. This could be a genuine metabolic effect or a placebo. Without controlled studies, it is impossible to say for certain.
NAD+ IV sessions are not cheap ($300–$800 per infusion) and typically require multiple sessions to maintain results. If you are considering it, go to a provider who can explain the mechanism, not just the marketing.
At Anova Med Spa, we offer NAD+ alongside our IV menu so clients can decide based on their own research and goals. We do not oversell it — we explain it.